Intan Technologies, LLC: low-noise amplifier microchips for electrophysiology, EKG, EMG, EEG, ECoG, and neural recording headstages and bio instrumentation

RHS2116 stimulator/amplifier chip

RHS2116 16-channel stimulator/amplifier digital electrophysiology chip in a 7mm x 7mm plastic QFN package.

RHS2116 chip datasheet

Intan Stimulation/Recording system

See biological signals acquired using RHS2000 series chips.

RHS2000 RhythmStim USB/FPGA interface

Bond pad diagram for RHS2116 bare die

Pricing information


RHS2000 series digital stimulator/amplifier chips

The Intan Technologies RHS2116 microchip is a complete bidirectional electrophysiology interface consisting of an array of 16 independent stimulator/amplifier channels.  Each channel contains a low-noise biopotential amplifier with configurable bandwidth and a programmable constant-current stimulator capable of generating customized biphasic stimulation pulses optimized for use with for extracellular microelectrodes.

In practice, an array of electrodes is connected directly to the chip, and a digital bus is used to control stimulation and read digitized electrode signals.  By interfacing electrodes directly with a digital command and data stream, the RHS2116 replaces all analog instrumentation circuitry in extracellular recording and stimulation systems.

The RHS2116 is suitable for a wide variety of neural interfacing applications.  Innovative circuit architecture combines stimulators, charge recovery circuits, amplifiers, analog and digital filters, a multiplexed analog-to-digital converter (ADC), and a flexible electrode impedance measurement module on a single silicon chip.

The bandwidths of the amplifiers are selected by means of programmable registers on the chip.  This flexibility allows the chips to be optimized for different types of signals (e.g., single units, local field potentials, EEG, ECoG).  Integrated charge-recovery circuits and fast amplifier settling can be employed following stimulation pulses to minimize recording artifacts.  A 16-bit on-chip ADC can sample each channel up to 40 kSamples/s with microvolt sensitivity.  The DC potential of each electrode may also be measured over a wide voltage range.  Additional on-chip circuitry enables in situ electrode impedance measurements at multiple frequencies.

RHS2116 chips are packaged in standard 7mm × 7mm QFN surface mount packages, or available in bare die form.  The small footprint and low power consumption of the multi-channel chips enable the miniaturization of front end electronics for miniature headstages and other portable biopotential interface systems.

RHS2000 Series Family

  • RHS2116 16-channel stimulator/amplifier chip with unipolar inputs and one common reference input.

RHS2116 Features

  • Fully integrated electrophysiology interface chip with 16 channels of low-noise amplifiers and constant-current stimulators controlled by serial digital interface (industry-standard SPI bus)
  • Stimulators source and sink currents ranging from 10 nA to 2.55 mA over an 18 V range with integrated compliance monitors
  • Integrated charge-recovery circuits and fault current detection module
  • Low input-referred noise: 2.4 microvolts rms typical
  • On-chip 16-bit ADC supports sampling 16 amplifier channels up to 40 kSamples/s each
  • Upper cutoff frequency of all amplifiers set by on-chip registers; adjustable from 100 Hz to 20 kHz
  • Lower cutoff frequency of all amplifiers set by on-chip registers; adjustable from 0.1 Hz to 1000 Hz
  • Fast amplifier artifact recovery for post-stimulus recording
  • Integrated multi-frequency in situ electrode impedance measurement capability
  • Individual amplifier and stimulator enable/disable for power minimization

RHS2116 Applications

  • Miniaturized multi-channel headstages for extracellular neural recording and stimulation
  • Low-power wireless headstages or backpacks for electrophysiology experiments
  • Multielectrode array (MEA) in vitro recording and stimulation systems
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